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Department of Life Sciences
Deepak Sehgal
Professor and Head,
Department of Life Sciences,
School of Natural Sciences
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Education Details
Ph.D. Biochemistry (IARI), 1991
M.Phil. Molecular biology (University of Poona), 1987
M.Sc. Animal Genetics and Breeding (NDRI), 1983
Professional Experience:
After Ph.D., Professor Deepak Sehgal was engaged in research at University of Maryland (USA), University of Sussex (UK), Indian Institute of Science (Bangalore), International Centre for Genetic Engineering and Biotechnology (New Delhi), Invitrogen (USA) and PanaceaBiotec Ltd. (New Delhi). He also taught and coached the students at ICGEB and Panacea Biotec in the fields of Virology and Molecular Biology.
Research Interests:
Genetic Engineering, Protein Expression Systems, Drug Development
Select Publications:
Kalia M, Chandra V, Rahman AM, Sehgal D and Jameel S (2009) Heparan sulfate proteoglycans are required for cellular binding of the Hepatitis E Virus ORF2 capsid protein and for viral Infection. Journal of Virology 83:12714-12724.
(2006) Expression and processing of Hepatitis E Virus ORF1 nonstructural polyprotein. Virol. J. 3: 38.

(2006) Inhibition of Hepatitis B Virus DNA replicative intermediate forms by recombinant interferon-gamma. World J Gastroenterology 12(19): 3006-14.

Zafrullah M, Khursheed Z, Yadav S, Sehgal D, Jameel S and Ahmad F (2003) Acidic pH enhances structure and structural stability of the capsid protein of Hepatitis E Virus. Biochem. Biophys. Res. Commun. 313: 67-73.

Sehgal D, Malik PS and Jameel S (2003) Purification and diagnostic utility of the Hepatitis E Virus capsid protein expressed in insect larvae. Protein Expr. Purif. 27: 27-34.

Korkaya H, Jameel S, Gupta D, Tyagi S, Kumar R, Zafarullah M, Mazumdar M, Lal SK, Xiafong L, Sehgal D, Das SR and Sahal D (2001) The ORF3 protein of Hepatitis E Virus binds to Src homology 3 domains and activates MAPK. J. Biol. Chem. 9: 42389-400.

Sehgal  D and Gopinathan KP (1998) Over expression of Green Fluorescent Protein in Bombyx mori using baculovirus expression vector system. Biotechniques 25: 997-1007.

Acharya A, Sriram S, Sehrawat S, Rahman M, Sehgal  D and Gopinathan KP (2001) Bombyx mori nucleopolyhedrovirus: Molecular biology and biotechnological applications for large-scale synthesis of recombinant proteins. Curr. Sci. 83: 4555-465.

Sehgal D and Vijay IK (1994) A method for the high efficiency of water soluble carbodiimide-mediated amidation. Analytical Biochemistry 218: 87-91

Sehgal D, Santha IM and Mehta SL (1992) Purification of Oxalyl CoA Synthetase enzyme from Lathyrus sativus and raising antibodies. J. Pl. Biochem. Biotech. 1: 97-100.
National & International Recognition:
Wellcome Trust Grant, University of Sussex, UK (2005 ).

DBT fellowship,  Indian Institute of Science, Bangalore (1996)

DBT Grant at ICGEB, New Delhi  (2005)

Member, Evaluation Committee for Central Silk Board, Mysore  (2004)

Post doctoral fellowship at University of Maryland, USA (1992)

ICAR Senior Research Fellowship, IARI, New Delhi. (1987)
Executive Summary:
Professor Sehgal started his scientific career by studying Masters in Animal Genetics and Breeding from National Dairy Research Institute, Karnal where he developed a method to predict the quality attributes of dairy animals by observing sex chromatin. He pursued M.Phil. in Molecular Biology at university of Poona whereby he demonstrated that in chicken, the messages for eye lens crystalline were present as early as the gastrula stage. After that Dr. Sehgal moved to do his Doctorate in Biochemistry from Indian Agricultural Research Institute, New Delhi where he identified the gene, for neurotoxin synthesis, in wild pea which is responsible for lower limb paralysis. For his Post doctorate, Dr. Sehgal joined University of Maryland, USA where he worked on protein purification.  His second Post Doctorate was at Indian Institute of Science, Bangalore whereby his major accomplishment was to show that caterpillar Bombay mori could be used as Bioreactors for protein synthesis. Further, he was appointed as a Senior Research Scientist in department of Virology at International Centre for Genetic Engineering and Biotechnology, New Delhi. He worked on various aspects of HEV and also found a putative drug combination to reduce genomic load of Hepatitis B virus. He received Welcome Research grant and worked on Drosophila Expression System at University of Sussex (UK). Professor Sehgal joined Invitrogen (USA) as a group Leader of Protein expression and purification. Subsequently, he joined PanaceaBiotec Ltd. a Biopharmaceutical company where he was group leader and Projects coordinator to develop anti cancer drugs. He coached the M.Sc. trainees in Molecular Biology to clone various genes into in house designed vectors. Professor Sehgal has a great passion for the innovative research and aptitude for teaching.

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