SCHOOL OF NATURAL SCIENCES
NATURAL SCIENCES
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Faculty
Department of Life Sciences
Richa Priyadarshini
Assistant Professor,
Department of Life Sciences,
School of Natural Sciences
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Education Details
PhD in Microbiology (2007) - University of North Dakota, USA
Masters in Microbial Gene Technology (2002) - Madurai Kamaraj University, India
Bachelors in Microbiology (2000) - University Of Delhi, India
Professional Experience:
2010-2012 - Post-doctoral Fellow, Forsyth Institute, (affiliated to Harvard School of Dental Medicine), USA
2007-2010 - Post-doctoral Associate, Yale University, USA
Research Interests:
Bacterial resistance to antibiotics is growing rapidly and as a consequence need for development of new antibiotics is desired. Hydrolases represent attractive targets for new antibiotics as the activities of hydrolases are required to inset new peptidoglycan and overproduction of these enzymes which leads to cell lysis. The broad area of my research interest is to develop new antibiotics targets. My research interests include:
  • Study temporal and spatial regulation of cell wall hydrolases in bacterial cells using Caulobacter crescentus
  • Study the regulation of peptidoglycan hydrolases during cell growth and cell division.
  • Role of hydrolases in bacterial cell morphogenesis.
  • Development of hydrolases as the antibiotic targets.
Select Publications:
Richa Priyadarshini , Carla Cugini , Annette Arndt , Tsute Chen , Natalia O. Tjokro , Steve D. Goodman and Mary-Ellen Davey. 2012. The Nucleoid-Associated Protein HU-beta Affects Global Gene Expression in Porphyromonas gingivalis. Microbiology. Nov22

Jason Hocking, Richa Priyadarshini, Constantin Takacs, Teresa Costa, Natalie Dye, Lucy Shapiro, Waldemar Vollmer, and Christine Jacobs-Wagner. 2012. Osmolality-dependent relocation of penicillin-binding protein PBP2 to the division machinery in Caulobacter crescentus. Journal of Bacteriology 195 (12): 3116-27

Christine Alberti-Segui, Annette Arndt, Carla Cugini, Richa Priyadarshini and Mary E. Davey. 2010. HU Protein Affects Transcription of Surface Polysaccharide Synthesis Genes in Porphyromonas gingivalis. Journal of Bacteriology 192(23):6217-29.

Teresa Costa, Richa Priyadarshini, and Christine Jacobs-Wagner. 2008. Localization of PBP3 in Caulobacter crescentus is highly dynamic and largely relies on its functional transpeptidase domain. Journal of Molecular Microbiology 70(3):634-51.

Richa Priyadarshini, Miguel A. de Pedro, and Kevin D. Young. 2007. Role of Peptidoglycan amidases in the development and morphology of the division septum in Escherichia coli. Journal of Bacteriology 189: 5334-5347.

Richa Priyadarshini, David L Popham, and Kevin D. Young. 2006. Daughter Cell Separation by penicillin-binding proteins and peptidoglycan amidases in Escherichia coli. Journal of Bacteriology 188: 5345-5355.

Bernadette M. Meberg, Avery L. Paulson, Richa Priyadarshini, and Kevin D. Young. 2004. Endopeptidase penicillin-binding proteins 4 and 7 play auxiliary roles in determining uniform morphology of Escherichia coli. Journal of Bacteriology 186: 8326-8336.
National & International Recognition:
Anderson Post-doctoral Fellowship by Yale University (2007-2008)

NSF North Dakota EPSCoR Doctoral Dissertation Grant (research support) for advanced studies and research in bacterial cell separation in E. coli.

Selected and funded by the Government of India to be a part of Indian delegation at the 55th Nobel Laureate’s Meeting in Lindau, Germany in 2005.

Awarded NET by the Council for Scientific and Industrial Research (CSIR), India (2002)

Student Grant Award for Molecular Genetics of Bacteria and Phage Meeting, Madison, Wisconsin (2005) and American Society for Microbiology General Meeting and Science Congress (2004)

Poster and Paper Presentations:
Richa Priyadarshini, Carla Cugini , Natalia O. Tjokro , Steve D. Goodman and Mary-Ellen Davey. Role of Histone-like protein HU in Porphyromonas ginigvalis. General meeting, American Society for Microbiology, San Fransisco ( June 2012)

Richa Priyadarshini, T. Costa, C. Jacobs-Wagner. Assembly of peptidoglycan synthetic machinery in Caulobacter crescentus. 3rd American Society for Microbiology conference on Prokaryotic Development, Cambridge, Massachusetts, 2009.

Richa Priyadarshini, M. A. de Pedro, K. D. Young. Division site associated ring-like structures in sacculi purified from Escherichia coli amidase mutants. General meeting, American Society for Microbiology, Orlando, Florida ( May 2006)

Richa Priyadarshini and K. D. Young. Role of penicillin binding proteins and amidases in cell separation and chaining in Escherichia coli. Bacteria and Phage Genetics Conference, Madison, Wisconsin (August, 2005)

Richa Priyadarshini and K. D. Young. Role of amidases and penicillin binding proteins in cell separation and chaining in Escherichia coli. American Society for Microbiology, Atlanta, (June, 2005)

Richa Priyadarshini and K. D. Young. Role of penicillin binding proteins in bacterial cell separation in Escherichia coli. Scholarly Forum, University of North Dakota, Grand Forks (2005)

Richa Priyadarshini and K. D. Young. Role of penicillin binding proteins in bacterial cell separation in Escherichia coli. Medicine and Health Sciences, Basic Sciences Retreat. Grand Forks (2004)

Richa Priyadarshini and K. D. Young. Role of penicillin binding proteins in bacterial cell separation. American Society for Microbiology, New Orleans. (2004)

Executive Summary:

Dr. Richa Priyadarshini is a doctorate from the University of North Dakota, USA where she worked in the lab of Dr. Kevin Young on bacterial cell division. Thereafter, she pursued her post-doctoral research in the lab of Dr. Christine Jacob-Wagner at the Yale University where the focus of her research was bacterial cell morphogenesis. Subsequently, she joined the Forsyth Institute as postdoctoral fellow where the focus of her research was Histone-like protein, HU in Porphyromonas gingivalis. Dr. Priyadarshini has published many papers in leading international journals.

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