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SCHOOL OF NATURAL SCIENCES
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Faculty
Department of Chemistry
Subhabrata Sen
Associate Professor and Head,
Department of Chemistry,
School of Natural Sciences
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Education Details
Ph.D: University of Missouri-Columbia, Columbia, MO, USA; Advisor: Dr. Shon R. Pulley, 2001
M.Sc: University of Kalyani, Kalyani, West Bengal, India, 1996
Professional Experience:
Associate Professor: Shiv Nadar University (present)
Associate Director: GvkBioscience located in Hyderabad, AP, India
Principal Scientist: Jubilant Chemsys located in Noida, UP, India
Senior Manager: Pfizer VMPS, Mumbai, India
Senior Scientist: BASF-India, Mumbai India
Scientific manager: Syngene International Private Limited, Bangalore, India
Scientist-1: Chemocentryx Inc., Mountain View, California, USA
Post doctoral researcher with A. I. Meyers, Colorado State University, Fort Collins, CO, USA
Research Interests:
  1. Diversity oriented synthesis of novel heterocycles
  2. Target based approaches to access novel small molecules as drugs for type II diabetes
  3. New strategies towards nitrogen heterocycles
  4. Multicomponent reactions to access novel heterocycles
  5. Catalyst development for C-C and C-X bond forming reaction
Group News:

  1. Sen received the prestigious Seibold-Collegium Fellowship of Julius Maxmilian University of Wuerzburg, Wuerzburg, Germany.
Courses Taught:
  1. CHY 101 (General Chemistry for 1st year under graduate students): Monsoon 2013/Spring 2014/Monsoon 2014
  2. CCC-CHY 401 (Small molecules and natural remedies for all under graduates all stream): Spring 2013
  3. UWE-CHY 120 (Molecules and medicine for all undergraduates): Spring 2014/Spring 2015
  4. CHY 502 (Advanced Synthetic Organic Chemistry for PhD students): Spring 2014/ Monsoon 2014, Monsoon 2015
  5. CHY 213 (Chemical Analysis lab for Chemistry Undergraduates): Spring 2015
Publications:
  1. Jyoti Chauhan, Tania Luthra, Rambabu Gundla, Antonio Ferraro, Ulrike Holzgrabe, Subhabrata Sen*, Organic and Biomolecular Chemistry, 2017, Just Accepted, DOI: 10.1039/C7OB02230A

  2. Tania Luthra, Rahul Agarwal, Uma Adepally,* Mamidala, Estari, Subhabrata Sen* A novel library of α-arylketones as potential inhibitors of α-glucosidase: Their design, synthesis, in vitro and in vivo studies, Scientific Reports, 2017, 7, 13246 (DOI:10.1038/s41598-017-13798-y).

  3. Santanu Hati, Ulrike Holzgrabe, Subhabrata Sen* Oxidative dehydrogenation of C-C and C-N bonds: A convenient approach to access diverse (dihydro) heteromatic compound, Beilstein J. Org. Chem. 2017, 13, 1670-1692.

  4. Suresh Poudapally, Shankar Battu, Loka Reddy Velatooru, Murali Satyanarayana Bethu, Janapala Venkateswara Rao, Somesh Sharma, Subhabrata Sen, Narender Pottabathini, Vijaya Bhaskara Reddy Iska, Vidya Katangoor, Synthesis and Biological Evaluation of Novel Quinazoline-Sulfonamides as Anti-Cancer Agents, Bioorganic and Medicinal Chemistry Letters, 2017,

  5. Santanu Hati and Subhabrata Sen* Cerium Chloride Catalyzed, 2-Iodoxybenzoic Acid Mediated Oxidative Dehydrogenation of Multiple Heterocycles at Room Temperature, European Journal of Organic Chemistry. 2017, 1277-1280

  6. Pratip Kumar Dutta, Arpi Majumder, Sanjay Dutta, Basab Bijayi Dhar, Parthapratim Munshi and Subhabrata Sen* Solvent free, palladium catalyzed highly facile synthesis of diaryl disulfides from aryl thiols, Tetlett, 2017, 58, 527-530

  7. Naveen Kumar, Santanu Hati, Parthapratim Munshi , Seema Sehrawat, Subhabrata Sen and Shailja Singh* A novel spiroindoline targets cell cycle and migration via modulation of microtubule cytoskeleton, Molecular and Cellular Biochemistry, 2017, 429, 11-21

  8. Dandugudumula Ramu, Swati Garg, R. Ayana, A. K. Keerthana, Vijeta Sharma, Subhabrata Sen, Soumya Pati and Shailja Singh* Novel β-carboline-quinazolinone hybrids disrupt Leishmania donovani redox homeostasis and show promising antileishmanial activity, Biochemical Pharmacology, 2017, 129, 26-42

  9. Chandramohan Bathula, Shreemoyee Ghosh, Santanu Hati, Sayantan Tripathi, Shailja Singh, Saikat Chakrabarti, Subhabrata Sen* Bioisosteric modification of known fucosidase inhibitors to discover a novel inhibitor of α-L-fucosidase, RSC Advances, 2017, 7, 3563-3572.

  10. Santanu Hati, Sayantan Tripathi, Pratip K. Dutta, Rahul Agarwal, Ramprasad Srinivasan, Ashutosh Singh, Shailja Singh, Subhabrata Sen* Spiro[pyrrolidine-3, 3´-oxindole] as potent anti-breast cancer compounds: Their design, synthesis, biological evaluation and cellular target identification, Scientific Report 2016, 6: 32213, 1-10.

  11. Chandramohan Bathula, Sayantan Tripathi, Ramprasad Srinivasan, Kunal Kumar Jha, Arnab Ganguly, G. Chakraborty, Shailja Singh, Parthapratim Munshi, Subhabrata Sen* Synthesis of novel 5-arylidenethiazolidinones with apoptotic properties via a three component reaction using piperidine as a bifunctional reagent, Organic and Biomolecular Chemistry, 2016, 14, 8053-8063 (Accepted as inner cover page).

  12. Santanu Hati, Pratip K. Dutta, Sanjay Dutta, Parthapratim Munshi and Subhabrata Sen* Accessing Benzimidazoles via a Ring Distortion Strategy: An Oxone Mediated Tandem Reaction of 2-Aminobenzylamines, Org. Lett., 2016, 18, 3090–3093.

  13. Rajanikanth Mamidala, Papiya Mazumdar, Chandramohan Bathula, Rahul Agarwal, Kunal Kumar Jha, Hemanta Majumdar, Parthapratim Munshi, Subhabrata Sen* Identification of Leishmania donovani Topoisomerase 1 inhibitors via intuitive scaffold hopping and bioisosteric modification of known Top 1 inhibitors Scientific Reports, 2016, 6, 26603 (1-12).

  14. Rahul Agarwal, Ashutosh Singh and Subhabrata Sen, Role of Molecular Docking in Computer Aided Drug Design and Development, Chapter-1, Applied Case Studies and Solutions in Molecular Docking-Based Drug, Design, ISBN 9781522503620, 2016, Publisher: IGI Global.

  15. Santanu Hati and Subhabrata Sen* Synthesis of Quinazolines and Dihydroquinazolines: o-Iodoxybenzoic Acid Mediated Tandem Reaction of o-Aminobenzylamine with Aldehydes, Synthesis. 2016, 48, 1389-1398

  16. Santanu Hati and Subhabrata Sen* N-bromo-succinimide promoted synthesis of β-carbolines and 3, 4-dihydro-β-carbolines from tetrahydro-β-carbolines Tetlett2016,57, 1040-1043

  17. Chandramohan Bathula, R. Mamidala, C. Tulluri, Rahul Agarwal, K. K. Jha, U. Adepally, Ashutosh Singh, Parthapratim Munshi, M. Thirumalacharya and Subhabrata Sen*Substituted furopyridinediones as novel inhibitors of α-glucosidase, RSC Advances, 2015,5,90374-90385

  18. Chandramohan Bathula, Poonam Dangi, Santanu Hati, Rahul Agarwal, Ashutosh Singh, Parthapratim Munshi, Shailja Singh and Subhabrata Sen* Diverse synthesis of natural product inspired fused and spiro-heterocyclic scaffolds via ring distortion and ring construction strategies, New Journal of Chemistry, 2015, 39, 9281-9292

  19. Papiya Majumdar, Chandramohan Bathula, Suparna M. Basu, Subhendu K. Das, Rahul Agarwal, Santanu Hati, Ashutosh Singh, Subhabrata Sen,* Benu Brata Das*, Design, synthesis and evaluation of thiohydantoin derivatives as potent topoisomerase I (Top1) inhibitors with anticancer activity, European Journal of Medicinal Chemistry, 2015, 102, 540-551

  20. Santanu Hati, Sanjay M. Madurkar, Chandramohan Bathula, Chiranjeevi Thulluri, Rahul Agarwal, Faiza Amber Siddiqui, Poonam Dangi, Uma Adepally, Ashutosh Singh, Shailja Singh*, Subhabrata Sen*, Design, synthesis and biological evaluation of small molecules as potent glucosidase inhibitors, European Journal of Medicinal Chemistry, 2015, 100, 188-196

  21. Ganesh Prabhu, Shalini Agarwal, Vijeta Sharma, Sanjay M. Madurkar, Parthapratim Munshi, Shailja Singh,* Subhabrata Sen*, A natural product based DOS library of hybrid systems, European Journal of Medicinal Chemistry, 2015, 95, 41-48

  22. Chandramohan Bathula, Shailja Singh and Subhabrata Sen*, Diversity Oriented Synthesis of Novel anti-malarials, Systems and Synthetic Biology, 2015,9 (Supp 1), 49

  23. Santanu Hati, Sudeepto Bhattacharya, Subhabrata Sen*, Innovative techniques to discover novel antimalarials, Systems and Synthetic Biology, 2015,9 (Supp 1), 39

  24. Vijeta Sharma, Shalini Agarwal, Sanjay M Madurkar, Gaurav Datta, Poonam Dangi, Ramu Dandugudumula, Subhabrata Sen,* and Shailja Singh*, Diversity-oriented synthesis and activity evaluation of substituted bicyclic lactams as anti-malarial against Plasmodium falciparum, Malaria Journal, 2014, 13, 1-11

  25. Sudeepto Bhattacharya and Subhabrata Sen,Chapter-14, Applications of Metaheuristics in Process Engineering, ISBN 978-3-319-06507-6, 2014, Publisher :Springer

  26. Subhabrata Sen*, Ganesh Prabhu, Chandramohan Bathula, Santanu Hati, Diversity Oriented Asymmetric Synthesis, Synthesis, 2014, 46, 2099-2121

  27. Rajinikanth Mamidala, V. Surendra Babu Damerla, Rambabu Gundla, M. Thirumala Chary, Y. L. N. Murthy and Subhabrata Sen*, , 2014, 4, 10619-10626

  28. Nagamani Sukumar, Michael P. Krein, Ganesh Prabhu, Sudeepto Bhattacharya and Subhabrata Sen,Network Measures for Chemical Library Design, Drug Development Research, 2014, 75, 402–411

  29. Subhabrata Sen*, Rajanikanth Mamidala, Rambabu Gundla and M. T. Charya, Diversity Oriented Synthesis of Macrocyclic Diaryl Ethers by Dötz Benzannulation, Asian Journal of Organic Chemistry, 2013, 2, 862–868

  30. Ramu Surakanti, S. Sanivarapu, Chiranjeevi Thulluri, Pravin S. Iyer, Raghuram S. Tangirala, Rambabu Gundla, Dr. Uma Addepally, Y. L. N. Murthy, Lakshmi Velide and Subhabrata Sen*, Synthesis of Privileged Scaffolds by Using Diversity-Oriented Synthesis Chemistry An Asian Journal, 2013, 8, 1168–1176

  31. Subhabrata Sen*, Siva R. Kamma, Rambabu Gundla, Uma Adepally, Santosh Kuncha, Sridhar Thirnathi and U. Viplava Prasad, A reagent based DOS strategy via Evans chiral auxiliary: highly stereoselective Michael reaction towards optically active quinolizidinones, piperidinones and pyrrolidinones, ., 2013, 3, 2404-2411

  32. Andrew M.K. Pennell, James B. Aggen, Subhabrata Sen, Wei Chen, Yuan Xu, Edward Sullivan, Lianfa Li, Kevin Greenman, Trevor Charvat, Derek Hansen, Daniel J. Dairaghi, J.J. Kim Wright, Penglie Zhang, 1-(4-Phenylpiperazin-1-yl)-2-(1H-pyrazol-1- yl)ethanones as novel CCR1 antagonists, Bioorganic & Medicinal Chemistry Letters, 2013, 23, 1228-1231.

  33. V. Surendra Babu Damerla, Chiranjeevi Tulluri, Dr. Rambabu Gundla, Lava Naviri, Prof. Uma Adepally, Pravin S. Iyer, Prof. Y. L. N. Murthy, Nampally Prabhakar and Subhabrata Sen* Reagent-Based DOS: Developing a Diastereoselective Methodology to Access Spirocyclic- and Fused Heterocyclic Ring Systems, Chemistry An Asian Journal, 2012, 7, 2351–2360.

  34. Subhabrata Sen,* Siva R. Kamma, Venkata R. Potti, Y.L.N. Murthy, Avinash B. Chaudhary, Diversity-oriented synthesis of amino acids using chiral enolates, Tetrahedron Letters, 2011, 52, 5585-5588.

  35. Subhabrata Sen,* Venkata R. Potti, Ramu Surakanti, Y. L. N. Murthy and Raghavaiah Pallepogu, Enantioselective synthesis of spirooxoindoles via chiral auxiliary (bicyclic lactam) controlled SNAr reactions, ., 2011, 9, 358-360

  36. Subhabrata Sen,* Kailaskumar Borate, Parag Kulkarni, Nandini R. Pai, Reaction of substituted alkynols with alkoxycarbene complexes of chromium: a facile synthesis of substituted α,β-unsaturated-γ-butyrolactones, Tetrahedron Letters, 2009, 50, 5001-5004

  37. Subhabrata Sen,* Parag Kulkarni, Kailaskumar Borate, Nandini R. Pai, Synthesis of novel oxygen heterocycles: 1,10-dioxa-cyclopenta[ a]fluorene and benzo[ b]naphtho[2, 1- d]furans via Dötz intramolecular benzannulation, Tetrahedron Letters, 2009, 50, 4128-4131

  38. Samir Ghosh, A. Sanjeev Kumar, G. N. Mehta, R. Soundararajan* and Subhabrata Sen, Formal synthesis of piperazinomycin, a novel antifungal antibiotic ARKIVOC, 2009, vii, 72-78

  39. Anuradha Gupta, Subhabrata Sen, Michael Harmata, and Shon R. Pulley, Synthesis of (S, S)-isodityrosine by Dotz benzannulation, 2005, 18, 7422-742

  40. Shon R. Pulley, Subhabrata Sen, Andrei Vorogushin, and Erika Swanson, Organic Letters, Diaryl Ethers Using Fischer Chromium Carbene Mediated Benzannulation, 1999, 1, 1721-1723.
Patents:
  1. Indian Patent Application, 2010, 46pp, IN2008KO01638
  2. US 7449576, 2008.
  3. US 7435831, 2008.
  4. US 7435830, 2008.
  5. WO/2007/027734, 2007.
  6. US 7157464, 2007.
  7. WO/2005/056015, 2005.
  8. WO/2003/105853, 2003.
Presentations:
Novel multicomponent reactions in the synthesis of bioactive heterocycles

Invited Presentation in Sixth European Workshop in Drug Synthesis, 15th-19th May, 2016, Certosa di Pontignano, Siena, Italy.

Invited Presentation in 4th International Conference on Asian Network for Natural and Unnatural Materials, 8th-11th June, 2016, National University of Singapore, Singapore.

Intuitive scaffold hopping strategy towards substituted furopyridinediones as novel inhibitors of α-glucosidase

Oral Presentation in International Conference on Pharmaceutical Bioinformatics, 2016, Pattaya, Thailand, 25th -27th January, 2016.

Multicomponent reactions in the synthesis of biologically interesting heterocycles

Invited lecture in Faculty of Medicinal Technology, Mahidol University, Nakhon Pathom, Thailand, 29th January, 2016

Diverse synthesis of natural product inspired fused and spiro scaffolds via ring distortion and construction strategy
  1. Oral Presentation in MedChem 2015, SelectBio conference, Hyderabad, Telengana, 10th -11th September, 2015.
  2. Oral Presentation in Bioheterocycles 2015, Metz, France, 8th -11th June, 2015
Library design: phenotypic screening and target based approaches

Invited lecture in Asian Network for Natural and Unnatural Materials in Department of Chemistry, University of Punjab, Chandigarh, 28th February-2nd March, 2015

Natural product inspired chiral hybrid systems via biology driven diversity oriented synthesis (BDDOS)

Invited lecture in Department of Physical Sciences and Mathematics in Nanyang Technical University, Singapore, October 27th, 2014

Synthesis of novel and privileged scaffolds via diversity-oriented synthesis followed by phenotypic screening against cancer cell lines.

Invited Lecture on Medchem 2013, IIT-Chennai, Chennai, Tamil Nadu, India, October 25th-26th, 2013

Michael reaction of oxazoldiinones with Nitrostyrene:Efficient Accesses to Optically Active Quinolizidinones, Piperidinones and Pyrrolidinones Evolution from auxiliary to catalytic asymmetric synthesis.

Invited Lecture on 2nd World Congress of Catalytic Asymmetric Synthesis, Beijing, China, May 12th-14th, 2012

Natural Product Inspired Spirocyclic and Fused systems from chiral Bicyclic Lactams.

Invited Lecture on Practical Applications of Modern Tools in Organic Synthesis and Purifications II, Pune, Maharashtra, India, April 2nd –April 4th, 2012

Posters:

Sen Subhabrata, Prabhu Ganesh, Munshi Parthapratim, Singh, S., Stereoselective synthesis of “Privileged Scaffolds” by diversity oriented synthesis (DOS) followed by phenotypic screening. Poster presented on Tetrahedron Asia Conference 2014, Singapore.

Sen Subhabrata; Borate Kailashkumar; Kulkarni Parag and Pai, N. R., Synthesis of dibenzofuran and a,b-unsaturated-g-butenolides via fischer chromium carbenes. Poster presented on 50th Tetrahedron Conference, Berlin 2007, Germany.

Pulley, Shon R.; Sen Subhabrata. Synthesis of Diaryl Ethers via Dötz Benzannulation: Optimization and Applications. Book of Abstracts, 221st ACS National Meeting, SanDiego, California, April 1-5 (2001), ORGN-315

Pulley, Shon R.; Sen Subhabrata. A Benzannulation Approach to Biaryl Ethers. Book of Abstracts, 33rd ACS Midwest Regional Meeting, Wichita, Kansas, November 4-6 (1998), ORGN-207
Funding:
Identifying novel candidates for breast cancer via Diversity Oriented Synthesis (DOS)

Department of Biotechnology, Pilot Grant, 25 lakhs, 2015-2018
Executive Summary:
My research group focusses on fundamental and applied research in synthetic organic chemistry. In the fundamental aspect we work on:
  1. Devising novel methodologies to access nitrogen heterocycles
  2. Metal mediated C-C and C-X bond forming reactions
  3. Multicomponent reactions
In the application part, we focus on:
  1. Diversity oriented synthesis
  2. Target based synthesis
    1. Type II diabetes
    2. Breast cancer
    3. Leishmania
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